Sunday, March 10, 2019

Molecular basis of inheritance: Previous Year Questions Part 2

MOLECULAR BASIS OF INHERITANCE

2013 MARCH
1.     The flow of genetic information is shown below. Name the processes a, b, c & d. (4 x ½ =2)
2.     Given below is the figure showing functioning of lac operon in presence of lactose. Redraw the figure and label the parts numbered to 1 to 6. (3)
3.     RNA is not an ideal genetic material because
a.   2’OH group of ribose is reactive and make it labile
b.   It is catalytic and hence reactive
c.    Both (a) and (b)
d.   None of the above (1)
2013 SAY
1.     Presence of lactose enhances the production of  galactosidase and other enzymes in bacteria. How will you explain this phenomenon?  (1)
2.     A DNA sequence needed for coding a peptide is given.
“CAAGTAAATTGAGGACTC”
(Hint: Codons and amino acids)
UUA
Leu
CCU
Pro
CAU
His
ACU
Thr
GUU
Val
GAG
Glu
a.   Write the complimentary mRNA coding sequence for this. (1)
b.   Find out the amino acid sequence of the peptide chain using the codons given in the hints. (1)
c.    If a mutation causes a change in the sixth codon CTC to CAC, it leads to a Mendelian disorder. Identify the disease and write the specific characteristics of the disease.             (2)
3.     Draw a flowchart showing the steps of Southern blot hybridization using radio labeled VNTR.    (3)
2014 MARCH
1.     “Prediction of the sequence of amino acids from the nucleotide sequence in mRNA is very easy, but the exact prediction of the nucleotide sequence in mRNA from the sequence of amino acids coded by mRNA is difficult.” (3)
a.   Which properties of the genetic code is the reason for above condition? Explain.
b.   Which are the stop codons in DNA replication?            
2.     Diagrammatic representation of ‘Central Dogma’ is given below. Observe the diagram carefully and redraw it making appropriate corrections.
3.     Observe the diagram and answer the questions:  (2)
a.   Identify the process shown in the figure and define it.
b.   Identify the structure B. Write any one function of it in the process shown in the diagram.
2014 SAY
1.     Diagram of components of DNA are given below. Identify and differentiate the two diagrams I and II. (1)
2.      (a) Identify the diagram and explain. (1)
         (b) In some cases DNA is produced from RNA. Name this process and give example. (1)
3.      (a) Paternity or maternity can be determined by certain scientific methods. What is it? Define. (1)
(b) Briefly write methodology involved in the technique. (1)
(c) Comment on its other applications.   (1)
2015 MARCH
1.     Explain transcription. A transcription unit in DNA is defined primarily by three regions. Write the names of any two regions. (2)
2.     (a) The steps in DNA fingerprinting are given below. Complete the flowchart (A &B).
 (b) Mention the applications of DNA fingerprinting. (3)
3.     The flow of genetic information is shown below. Name the process of (a) and (b). (1)
2015 SAY
1.     Observe the following diagram and answer the questions.
a.   Diagrammatically represent the changes take place when lactose is added to the medium.
b.   What is the role of z, y and a genes in this metabolic pathway? (3)
2.     Observe the diagram and answer the questions: (3)
a.   What is the difference in the replication processes in A strand and B strand?
b.   What is the role of DNA ligase in the replication process in B strand?
c.    What is meant by replication fork?

PART 3

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